Causes of Premature Ejaculation and available treatments
Between 30% and 40% of men are incapable of engaging in sexual intercourse for longer than 2 minutes due to premature ejaculation. This condition may be caused by physiological as well as psychological factors and is easily treated with dapoxetine, SSRIs, topical anesthetics and/or antibiotics. PE is a frequent comorbidity in men with erectile dysfunction, observed in over half of all ED patients. Premature ejaculation is treatable in 89% of cases.
How to Choose the Right ED Medication
PDE-5 inhibitors and alprostadil are the medications most commonly used for erectile dysfunction treatment. Of PDE-5 inhibitors, Viagra or sildenafil is the most effective and Stendra or avanafil is the one with the lowest incidence of side effects. Cialis or tadalafil has the longest duration of action and is also the cheapest if comparing the prices of the generics. Among brand-name PDE-5 inhibitors, Levitra is the cheapest. Alprostadil is available as injectable solution, intraurethral suppositories and topical cream. The success rates for treatment with alprostadil range between 56% and 100% depending on the form of the drug and the cause of ED. The side effects of alprostadil are mild and well-tolerated.
ED drugs: from the Past to The Future
Erectile dysfunction is a very common condition affecting up to 50% of men aged 40 to 70.
The oldest written source mentioning impotence dates to 8th century BC when people tried to treat this condition with herbal concoctions and magic rituals.
The first effective surgery that helped relieve ED was performed by Francesco Parona. Pharmacological treatments popular in the past included natural hormonal extracts (early 1900s) and intrapenile injections (1980s). The first of modern peroral ED drug (PDE-5 inhibitor), Viagra, was invented in 1988 and approved for use in 1998, followed by Levitra and Cialis.
New ED drugs currently in development: topical creams, melanocortin/dopamine activators, stem cell and genetic therapy, chloride channel blockers, new-generation PDE-5 inhibitors (similar to Viagra but with improved performance).
Causes of Impotence and Available Treatments
50% of all men in the world suffer from impotence. Among the physiological factors causing this disorder are cardiovascular conditions, infections, diabetes, neurological and hormonal conditions. Impotence triggered by physiological factors is treated with PDE-5 inhibitors, vacuum devices, penile injections or surgery. Psychological conditions causing impotence can’t be treated with Viagra but should be resolved by counseling. ED is also caused by certain surgeries, radiation treatment, antidepressants. Current ED treatment techniques help 98% of patients.
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