ED drugs: from the Past to The Future
Erectile dysfunction is a very common condition affecting up to 50% of men aged 40 to 70.
The oldest written source mentioning impotence dates to 8th century BC when people tried to treat this condition with herbal concoctions and magic rituals.
The first effective surgery that helped relieve ED was performed by Francesco Parona.
Pharmacological treatments popular in the past included natural hormonal extracts (early 1900s) and intrapenile injections (1980s). The first of modern peroral ED drug (PDE-5 inhibitor), Viagra, was invented in 1988 and approved for use in 1998, followed by Levitra and Cialis.
New ED drugs currently in development: topical creams, melanocortin/dopamine activators, stem cell and genetic therapy, chloride channel blockers, new-generation PDE-5 inhibitors (similar to Viagra but with improved performance).